Table 2.
Univerate and multivariate analysis of factors associated with survival and recurrence in Cohort I human CRCs
| Variables | Recurrence | Survival | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |||
| Univariate analysis | ||||||
| Age | 0.999 (0.986-1.011) | 0.819 | 0.998 (0.985-1.011) | 0.772 | ||
| Sex (female versus male) | 1.272 (0.964-1.677) | 0.089 | 1.212 (0.916-1.604) | 0.179 | ||
| Tumor size (≤5 versus >5 cm) | 0.833 (0.628-1.105) | 0.205 | 0.827 (0.621-1.101) | 0.193 | ||
| Tumor differentiation(well/moderate versus poor) | 0.184 (0.138-0.245) | <0.001 | 0.186 (0.139-0.249) | <0.001 | ||
| Tumor invasion(T1-T3 versus T4) | 0.350 (0.261-0.469) | <0.001 | 0.357 (0.265-0.480) | <0.001 | ||
| Lymph node metastasis (absent versus present) | 0.138 (0.100-0.190) | <0.001 | 0.136 (0.098-0.189) | <0.001 | ||
| Distant metastasis (absent versus present) | 0.114 (0.081-0.159) | <0.001 | 0.113 (0.081-0.157) | <0.001 | ||
| AJCC stage(I-II versus III-Ⅳ) | 0.134 (0.097-0.187) | <0.001 | 0.133 (0.095-0.186) | <0.001 | ||
| FOXK2 expression (low versus high) | 0.256 (0.192-0.340) | <0.001 | 0.250 (0.187-0.333) | <0.001 | ||
| Multivariate analysis | ||||||
| Tumor differentiation(well/moderate versus poor) | 0.760 (0.515-1.122) | 0.168 | 0.809 (0.544-1.202) | 0.294 | ||
| Tumor invasion(T1-T3 versus T4) | 0.638 (0.214-1.910) | 0.421 | 0.669 (0.218-2.058) | 0.484 | ||
| Lymph node metastasis (absent versus present) | 0.354 (0.123-1.013) | 0.053 | 0.336 (0.114-0.984) | 0.047 | ||
| Distant metastasis (absent versus present) | 0.527 (0.343-0.812) | 0.004 | 0.485 (0.314-0.749) | 0.001 | ||
| AJCC stage(I-II versus III-Ⅳ) | 0.475 (0.337-0.669) | <0.001 | 0.489 (0.344-0.694) | <0.001 | ||
| FOXK2 expression (low versus high) | 0.421 (0.304-0.582) | <0.001* | 0.415 (0.300-0.576) | <0.001* | ||