Table 3.
Univerate and multivariate analysis of factors associated with survival and recurrence in Cohort II human CRCs
| Variables | Recurrence | Survival | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |||
| Univariate analysis | ||||||
| Age | 0.998 (0.988-1.009) | 0.774 | 1.000 (0.989-1.011) | 0.951 | ||
| Sex (female versus male) | 1.070 (0.847-1.351) | 0.569 | 1.116 (0.880-1.415 | 0.367 | ||
| Tumor size (≤5 versus >5 cm) | 0.901 (0.709-1.146) | 0.396 | 0.877( 0.686-1.122) | 0.297 | ||
| Tumor differentiation(well/moderate versus poor) | 0.469 (0.370-0.593) | <0.001 | 0.449 (0.353-0.571) | <0.001 | ||
| Tumor invasion(T1-T3 versus T4) | 0.605 (0.461-0.796) | <0.001 | 0.607 (0.459-0.803) | <0.001 | ||
| Lymph node metastasis (absent versus present) | 0.193 (0.150-0.248) | <0.001 | 0.172 (0.132-0.222) | <0.001 | ||
| Distant metastasis (absent versus present) | 0.130 (0.095-0.178) | <0.001 | 0.111 (0.081-0.154) | <0.001 | ||
| AJCC stage(I-II versus III-Ⅳ) | 0.179 (0.138-0.230) | <0.001 | 0.159 (0.122-0.207) | <0.001 | ||
| FOXK2 expression (low versus high) | 0.349 (0.275-0.443) | <0.001 | 0.343 (0.270-0.438) | <0.001 | ||
| Multivariate analysis | ||||||
| Tumor differentiation(well/moderate versus poor) | 0.798 (0.614-1.039) | 0.094 | 0.802 (0.612-1.050) | 0.109 | ||
| Tumor invasion(T1-T3 versus T4) | 0.685 (0.516-0.910) | 0.009 | 0.765 (0.575-1.018) | 0.066 | ||
| Lymph node metastasis (absent versus present) | 1.266 (0.587-2.730) | 0.547 | 1.075 (0.499-2.320) | 0.853 | ||
| Distant metastasis (absent versus present) | 0.378 (0.266-0.538) | <0.001 | 0.331 (0.231-0.474) | <0.001 | ||
| AJCC stage(I-II versus III-Ⅳ) | 0.210 (0.093-0.473) | <0.001 | 0.216 (0.095-0.490) | <0.001 | ||
| FOXK2 expression (low versus high) | 0.740 (0.559-0.980) | 0.036* | 0.688 (0.515-0.919) | 0.011* | ||