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. 2019 May 31;9(13):3825–3839. doi: 10.7150/thno.33958

Figure 4.

Figure 4

NIR laser-triggered photothermal drug release from DOX@pPGNCs. (A) Diameter and zeta potential of GNCs, PGNCs, pPGNCs, DOX@PGNCs and DOX@pPGNCs. (B) TEM images of GNCs, PGNCs, pPGNCs, DOX@PGNCs and DOX@pPGNCs. Scale bar: 50 nm. (C) Temperature of PBS, GNCs, PGNCs, pPGNCs, DOX@PGNCs and DOX@pPGNCs upon 808 nm laser irradiation (0.7 W/cm2) for different time intervals. (D) Photothermal stability of DOX@pPGNCs undergoing five cycles of 808 nm laser irradiation (0.7 W/cm2) and then cooling to room temperature. (E) Diameter of GNCs, PGNCs, pPGNCs, DOX@PGNCs and DOX@pPGNCs in response to 808 nm laser irradiation (0.7 W/cm2) for different time intervals. (F) in vitro DOX release profiles from DOX@PGNCs and DOX@pPGNCs in PBS with or without 808 nm laser irradiation (0.7 W/cm2) for 5 min. Black arrows indicate the irradiation points. The data are presented as the mean ± SD (n = 3).