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Origin of regulatory T (Treg) cells in tumours. Depicted are the three scenarios – not mutually exclusive – that could account for the presence of Treg cells within tumours. Left, conversion of naive CD4+ T cells into peripheral Treg (pTreg) cells; centre, recruitment of thymus‐derived Treg (tTreg) cells from the circulation; right, expansion of tissue‐resident Treg cells.
