Table 3.
Final population pharmacokinetic estimates and bootstrap results for benzylpenicillin after administration of monthly injections of BPG in children and adolescents
| Parameter | Mean | Bootstrap, median (95% CI) |
|---|---|---|
| Objective function value | −265.078 | −300.214 (−458.616 to −161.877) |
| Structural model parameters | ||
| k el (h−1·70 kg−1) | 1.32 | fixed |
| V (L·70 kg−1) | 72.2 | 72.0 (64.0–84.2) |
| t ½, abs-1 (days) | 0.455 | 0.461 (0.174–0.948) |
| t ½, abs-2 (days) | 8.88 | 8.79 (5.71–12.5) |
| increase in t½, abs-2 with BMI ≥25 kg/m2 (%) | 86.5 | 86.8 (33.4–198) |
| Variable model parameters (shrinkage%) | ||
| IIV in V | 26 (9) | 24 (10–37) |
| IIV in t½, abs-1 | 78 (12) | 75 (40–107) |
| IIV in t½, abs-2 | 63 (12) | 62 (32–85) |
| IOV in t½, abs-2 | 30 (46) | 31 (20–48) |
| r (t½, abs-1, t½, abs-2) | −1 | fixed |
| r (t½, abs-2, V) | −0.746 | −0.808 (−1.00 to −0.316) |
| RV (%) | 35 (13) | 34 (30–38) |
k el, elimination rate constant; t½, abs, absorption t½; IIV, interindividual variability; IOV, interoccasion variability; RV, residual variability. IIV, IOV and RV are presented as 100% × √variability estimate.