Table 3.
Comparison of 100% insulin degludec (IDeg) and 75% IDeg dosing for glycaemic ranges, hypoglycaemic events, coefficient of variation and for glycaemia, based on time of day (night‐time or daytime)
| 100% IDeg | 75% IDeg | P | |
|---|---|---|---|
| Night‐time (12:00 am to 6:00 am) | |||
| Timeeuglycaemia, min | 695 ± 228 | 947 ± 350 | 0.059 |
| Timeeuglycaemia (%) | 43 ± 12 | 54 ± 20 | 0.10 |
| Timehypoglycaemia, min | 105 (8‐300) | 195 (0‐330) | 0.39 |
| Timehypoglycaemia (%) | 6 (0.5‐21) | 12 (0‐18) | 0.64 |
| Timehyperglycaemia, min | 755 ± 397 | 582 ± 379 | 0.23 |
| Timehyperglycaemia (%) | 45 ± 23 | 33 ± 22 | 0.17 |
| Hypoglycaemic events (n) (per participant over 5 days) | 1 (1‐3) | 1.7 ± 1.5 | 0.99 |
| CVglycaemia (%) | 39 ± 13 | 40 ± 11 | 0.86 |
| Daytime (6:00 am–12:00 am) | |||
| Timeeuglycaemia, min | 2732 ± 686 | 2739 ± 1342 | 0.49 |
| Timeeuglycaemia,% | 60 ± 14 | 57 ± 24 | 0.31 |
| Timehypoglycaemia, min | 165 (53‐210) | 105 (38‐405) | 0.82 |
| Timehypoglycaemia, % | 3 (1.5‐5.5) | 2 (1.5‐9) | 0.93 |
| Timehyperglycaemia, min | 1677 ± 789 | 1598 ± 799 | 0.71 |
| Timehyperglycaemia, % | 36 ± 16 | 38 ± 25 | 0.75 |
| Hypoglycaemic events (n) | 4 ± 2.5 | 2 (1.5–6) | 0.44 |
| CVglycaemia, % | 38 ± 6 | 38 ± 7 | 0.95 |
Abbreviations: CV, coefficient of variation; IDeg, insulin degludec.
Values are given as mean ± SD or median (25‐75 percentile).