Table 1.
Comparison of donor and preservation characteristics of livers in the preclinical study (Part A)
| DHOPE (n = 6) | Control (n = 9) | P value | |
|---|---|---|---|
| Donor characteristics | |||
| Age (y) | 64 (57‐70) | 62 (52‐64) | .29 |
| Sex (male) | 3 (50%) | 6 (67%) | .62 |
| Type of donor | .23 | ||
| DCD | 6 (100%) | 6 (67%) | |
| DBD | 0 | 3 (33%) | |
| Cause of death | .57 | ||
| Cardiovascular | 2 (33%) | 1 (11%) | |
| Post anoxic brain injury | 2 (33%) | 4 (44%) | |
| Trauma | 2 (33%) | 4 (44%) | |
| Reason rejected for transplantation | .35 | ||
| Age (DCD >60 y) | 5 (83%) | 4 (44%) | |
| Expected steatosis | 1 (17%) | 3 (33%) | |
| High transaminases | 0 | 1 (11%) | |
| Unknown | 0 | 1 (11%) | |
| Preservation characteristics | |||
| Cold ischemia time (min)a | 489 (452‐513) | 509 (409‐660) | .72 |
| Time from withdrawal of life support to cold flushb (min) | 33 (26‐53) | 43 (38‐79) | .13 |
| Time from circulatory arrest to cold flushc (min) | 15 (13‐23) | 20 (16‐23) | .49 |
Data are presented as number (percentage) or median (interquartile range).
DCD, donation after circulatory death; DBD, donation after brain death.
a
Cold ischemia time was defined as the interval between start aortic cold flush in the donor until the start of NMP or DHOPE.
b
The time interval between the discontinuation of mechanical ventilation and the start of aortic cold flush in the donor (international donor warm ischemia time).
c
The time interval between cardiac arrest and the start of aortic cold flush in the donor.