Table 1.
Differential glomerular expression of cytoskeleton‐related genes between 4‐ and 6‐week‐old Dahl rats and SHR rats
| Gene name | Gene symbol | Chromosomal location | Fold‐difference in expression | Function |
|---|---|---|---|---|
| Periplakin | Ppl | 10q12 | 4.17 | Intermediate filament binding |
| Moesin | Msn | Xq31 | 3.86 | Actin filament–membrane cross‐linking |
| Dynamin 1 | Dnm1 | 3p11 | 3.36 | Actin dynamics regulation |
| Tropomyosin 4 | Tpm4 | 16p14 | 2.73 | Actin binding |
| Thymoma viral proto‐oncogene 1 | Akt1 | 6q32 | 2.71 | Cell projection organization and biogenesis |
| Supervillin | Svil | 17q12 | 2.62 | Actin binding |
| Parvin, alpha | Parva | 1q33 | 2.62 | Actin cytoskeleton organization and biogenesis |
| Plastin 3 (T‐isoform) | Pls3 | Xq14 | 2.51 | Actin filament organization |
| Tropomyosin 1, alpha | Tpm1 | 8q24 | 2.23 | Actin filament capping |
| Microtubule‐associated protein, RP/EB family, member 1 | Mapre1 | 3q41 | 2.2 | Regulation of microtubule polymerization |
| Rho guanine nucleotide exchange factor (GEF) 17 | Arhgef17 | 1q32 | 2.1 | Actin cytoskeleton organization and biogenesis |
| Caldesmon 1 | Cald1 | 4q22 | 2.1 | Actin binding |
| Signal‐regulatory protein alpha | Sirpa | 3q36 | 2.04 | Actin filament organization |
| WD repeat domain 44 | Wdr44 | Xq12 | 2 | Vesicle recycling |
| Myosin Ib | Myo1b | 9q22 | 1.99 | Actin binding |
| Echinoderm microtubule‐associated protein‐like 4 | Eml4 | 6q12 | 1.97 | Microtubule stabilization |
| Actin‐related protein 2/3 complex, subunit 1B | Arpc1b | 12p11 | 1.89 | Cytoskeleton organization |
| Filamin, beta | Flnb | 15p14 | 1.87 | Actin binding |
| Myosin IC | Myo1c | 10q24 | 1.78 | Actin binding |
| Mitogen‐activated protein kinase 1 | Map3k1 | 2q14 | 1.78 | Actin filament polymerization |
| CAP, adenylate cyclase‐associated protein 1 (yeast) | Cap1 | 5q36 | 1.73 | Actin cytoskeleton organization and biogenesis |
| Kinesin light chain 1 | Klc1 | 6q32 | 1.59 | Microtubule motor activity |
| Src homology 2 domain‐containing transforming protein C1 | Shc1 | 2q34 | 1.57 | Actin cytoskeleton organization and biogenesis |
| ARP1 actin‐related protein 1 homolog A (yeast) | Actr1a | 1q54 | 1.55 | Cytoskeleton organization |
| Actin, beta | Actb | 12p11 | 1.54 | Cytoskeleton organization |
| A kinase (PRKA) anchor protein 2 | Akap2 | 5q24 | 1.51 | Actin filament organization |
| Spectrin alpha 1 | Spna1 | 13q24 | 0.19 | Cytoskeleton organization |
| Polyamine modulated factor 1 binding protein 1 | Pmfbp1 | 19q12 | 0.14 | Cytoskeleton organization and biogenesis |