Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Generation of aneuploidy by non‐functional SAC. The SAC is activated by the presence of unattached or misaligned kinetochores and prevents chromosome segregation errors. A non‐functional SAC allows cells with unattached or misaligned kinetochores to proceed from metaphase to anaphase, resulting in daughter cells with an abnormal chromosome number.
