Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 31;144(1):8–25. doi: 10.1002/ijc.31718

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

The complex relationship between aneuploidy and cancer. (a) Aneuploidy‐related growth and contact inhibition, ROS production, cell senescence can cooperate with environmental conditions and tumor suppressor activity to inhibit malignant transformation (round shaped cells represent nontransformed cells). (b) When prosurvival and protumorigenic events induced by aneuploidy (anchorage‐independent growth, transcriptional and metabolic reprogramming, GIN, CIN, immune escape) synergize with activation of oncogenes and favorable environmental conditions, cells carrying an aberrant chromosome number undergo malignant transformation (irregular shaped cells represent malignant cells; ROS, reactive oxygen species; CIN, chromosomal instability; GIN, genomic instability).