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. 2019 Jun 14;13:584. doi: 10.3389/fnins.2019.00584

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Copyright © 2019 Huang, Li, Zhou, Zhang, Chen, Wang, Xia, Liang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram showing the framework of discussion. The increasing AQP4 influences vascular and cytotoxic edema after SCC (shown as the red and gray arrows). Then, inhibition of AQP4 expression mediated by lentivirus significantly ameliorated cytotoxic edema after SCI. Furthermore, AQP4 is found as a regulator in the cytotoxic edema, probably dependent on regulating the COX5A expressional levels, which may affect membranous Na⁺-K⁺-ATPase by regulation of ATP generation (shown as the blue and purple arrow).