Table 1.
In Vitro Susceptibility of Various Organisms to Omadacycline and Comparator Agents
| Organism (# of Isolates) | Omadacycline | Doxycycline | Minocycline | Tetracycline | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC50 (mg/L) | MIC90 (mg/L) | MIC Range (mg/L) | MIC50 (mg/L) | MIC90 (mg/L) | MIC Range (mg/L) | MIC50 (mg/L) | MIC90 (mg/L) | MIC Range (mg/L) | MIC50 (mg/L) | MIC90 (mg/L) | MIC Range (mg/L) | |
| Gram‐positive organisms | ||||||||||||
| MRSA (n=39)4 | 0.25 | 0.5 | 0.125–1 | 0.125 | 8 | ≤ 0.06–8 | 0.25 | 8 | ≤ 0.06–16 | 0.25 | 64 | ≤ 0.06–64 |
| MRSA (n=1438)8 | 0.12 | 0.25 | 0.03–8 | – | – | – | – | – | – | – | – | – |
| S. pneumoniae (n=41)4 | ≤ 0.06 | 0.125 | ≤ 0.06–0.25 | 2 | – | ≤ 0.06–4 | 2 | 8 | ≤ 0.06–8 | 16 | 32 | ≤ 0.06–64 |
| E. faecalis (n=31)4 | 0.25 | 0.5 | 0.125–1 | 4 | 16 | ≤ 0.06–16 | 8 | 16 | 0.125–16 | 32 | 64 | 0.125– > 64 |
| E. faecium (n=24)4 | 0.25 | 0.5 | 0.125–0.5 | 2 | 8 | ≤ 0.06–16 | 8 | 16 | 0.125–32 | 32 | 64 | 0.125– > 64 |
| E. faecium (n=390)8 | 0.06 | 0.12 | ≤ 0.015–8 | – | – | – | – | – | – | – | – | – |
| Gram‐negative organisms | ||||||||||||
| H. influenzae (n=53)4 | 1 | 2 | 0.5–8 | 0.5 | 4 | 0.125–8 | – | – | – | 2 | 32 | 0.125–64 |
| M. catarrhalis (n=408)8 | 0.25 | 0.25 | 0.06–0.5 | – | – | – | – | – | – | – | – | – |
| K. pneumoniae (n=14)4 | 2 | 4 | 1–8 | 2 | 32 | 1–64 | 2 | 64 | 2– > 64 | 2 | > 64 | 0.5– > 64 |
| K. pneumoniae (n=1771)8 | 2 | 8 | 0.25– > 32 | – | – | – | – | – | – | – | – | – |
| Enterobacter cloacae species complex (n=572)8 | 2 | 4 | 0.25– > 32 | – | – | – | – | – | – | – | – | – |
| A. baumannii (n=441)8 | 4 | 8 | 0.06– > 32 | – | – | – | – | – | – | – | – | – |
| S. maltophilia (n=315)8 | 2 | 8 | 0.25– > 32 | – | – | – | – | – | – | – | – | – |
| Atypical organisms | ||||||||||||
| Mycoplasma pneumoniae (n=20)9 | 0.125 | 0.25 | 0.125–0.25 | 0.25 | 0.5 | 0.125–0.5 | – | – | – | 0.5 | 0.5 | 0.25–0.5 |
| Ureaplasma spp. (n=20)9 | 1 | 2 | 0.25–2 | 0.25 | 4 | 0.06–4 | – | – | – | 1 | 16 | 0.25–16 |
MIC = minimum inhibitory concentration; MIC50 = minimum concentration of antibiotic that inhibits 50% of the isolates; MIC90 = minimum concentration of antibiotic that inhibits 90% of the isolates; MRSA = methicillin‐resistant Staphylococcus aureus.