Table 1.
Treatable traits and defining criteria
| Treatable trait category | Treatable trait | Defining criteria |
|---|---|---|
| Pulmonary | Fixed airflow limitation | Postbronchodilator FEV1/FVC < 0.7 |
| Bronchodilator reversibility | Postbronchodilator increase in FEV1 AND/OR FVC ≥12% AND ≥200 ml | |
| Type 2 inflammation | Sputum eosinophil count ≥ 2% AND/OR blood eosinophils ≥ 450 cells per ul AND/OR FeNO > 50 ppb | |
| Neutrophilic inflammation | Sputum neutrophil count > 60% | |
| Cough | Asthma Quality of Life Questionnaire (AQLQ) Question 12 score ≤ 4 AND/OR Sino‐Nasal Outcomes Test (SNOT‐20) Question score 4 ≥ 3 | |
| Exercise‐induced respiratory symptoms | Medical history finding of “routine physical activity and/or physical exercise as asthma trigger” | |
| Bronchitis | Medical history finding of “Current AND/OR chronic bronchitis” | |
| Extra‐pulmonary | Rhinosinusitis | Medical history finding of “Allergic/Non‐allergic rhinitis active AND/OR sinusitis active” |
| Nasal polyps | Medical history finding of “Nasal polyps active” | |
| Obese | BMI > 30 | |
| Underweight | BMI < 18.5 | |
| Obstructive sleep apnoea | Epworth sleepiness scale score ≥ 11 | |
| Reflux | Medical history finding of “Reflux active” | |
| Vocal cord dysfunction | Medical history finding of “Vocal Cord Dysfunction active” | |
| Osteoporosis | Medical history finding of “Osteoporosis active” | |
| Cardiovascular disease | Medical history finding of “Coronary disease active” | |
| Eczema | Medical history finding of “Eczema active” | |
| Atopic | Positive skin prick test AND/OR blood IgE result | |
| Behavioural/psychosocial | Smoking | Medical history finding of “Current smoker” |
| Poor medication adherence | Medication Adherence Rating Scale (MARS) mean score <4.5 | |
| Psychiatric disease | Medical history finding of “Psychiatric disease active” | |
| Depression | Hospital Anxiety and Depression (HADS) depression domain score ≥ 11 | |
| Anxiety | Hospital Anxiety and Depression (HADS) anxiety domain score ≥ 11 |
Treatable traits presented here are based on that of Agusti et al.2 BMI, body mass index; FeNO, fraction of exhaled nitric oxide; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity.