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. 2018 Nov 1;234(7):10260–10269. doi: 10.1002/jcp.27695

Figure 2.

Figure 2

LOXL2 regulates angiogenic sprouting in EC. (a) Representative pictures of an angiogenic sprouting assay using shCtrl and shLOXL2 expressing EC at t = 72 hr. (b) Quantification of sprout length in a 72 hr angiogenic sprouting assay using shCtrl and shLOXL2 expressing EC (n = 4 + SD, Student’s t test). (c) Representative pictures of an angiogenic sprouting assay in pInducer20‐LOXL2 (Ind LOXL2) expressing EC stimulated with PBS (Vehicle) or doxycycline (Dox) at t = 72 hr. (d) LOXL2 overexpression increases sprouting length in an angiogenic sprouting assay (n = 4 + SD, Student’s t test); *p < 0.05 and **p < 0.01. EC: endothelial cells; LOXL2: lysyl oxidase‐like 2; mRNA: messenger RNA; PBS: phosphate‐buffered saline; shCtrl: shRNA control; shLOXL2: short hairpin‐mediated LOXL2 knockdown