Table 1.
Distribution of cases and controls by age, by population ancestry/ethnicity and by family history of cancer
| Controls (N = 1,199) | All cases (N = 1,207) | Pseudo‐incident1 cases (N = 663) | |
|---|---|---|---|
| Age 2 (years) | |||
| ≤30 | 9 | 0 | 0 |
| 31–40 | 61 | 20 | 13 |
| 41–50 | 265 | 269 | 171 |
| 51–60 | 429 | 465 | 250 |
| ≥61 | 435 | 453 | 229 |
| Mean age (SE) | 56.1 (0.3) | 57.5 (0.3) | 56.6 (0.4) |
| Range | 25–83 | 31–90 | 31–85 |
| Population ancestry/Ethnicity | |||
| Caucasian | 1,176 | 1,152 | 631 |
| Ashkenazi | 0 | 4 | 4 |
| African/Afro‐Caribbean | 1 | 3 | 1 |
| Arab/Berber/Asian/Arab+Berber | 4 | 13 | 6 |
| Mixed origin | 9 | 18 | 7 |
| Unknown | 9 | 17 | 14 |
| Number of cancers in family | |||
| Breast cancer (C50 + D05.1)3 | |||
| 0 | 851 | 0 | 0 |
| 1 | 261 | 0 | 0 |
| 2 | 68 | 294 | 167 |
| 3 | 14 | 467 | 252 |
| 4 | 3 | 280 | 161 |
| 5 | 1 | 104 | 46 |
| 6 | 0 | 46 | 28 |
| 7 | 1 | 11 | 6 |
| 8 | 0 | 5 | 3 |
| Ovarian cancer (C56) | |||
| 0 | 1,164 | 1,139 | 623 |
| 1 | 33 | 61 | 34 |
| 2 | 1 | 6 | 6 |
| 3 | 0 | 1 | 0 |
| 5 | 1 | 0 | 0 |
| Cancers from Lynch syndrome spectrum 4 | |||
| 0 | 781 | 678 | 396 |
| 1 | 306 | 335 | 158 |
| 2 | 81 | 130 | 74 |
| 3 | 20 | 44 | 23 |
| 4 | 5 | 14 | 8 |
| 5 | 5 | 5 | 4 |
| 6 | 1 | 0 | 0 |
| 7 | 0 | 1 | 0 |
1
Cases diagnosed with BC less than 5 years before enrollment in GENESIS.
2
Age at diagnosis for cases and age at inclusion for controls.
3
Number after excluding GENESIS index case and one affected sister.
4
Colon (C18), small bowel (C17), rectum (C19, C20), endometrium (C53, C54, C55), ovary (C56), stomach (C16), bile duct cancers (C24).