Table 4.

Distribution of MV and results of the association tests for ATM, CHEK2 and PALB2 using Align‐GVGD classifiers (Tavtigian et al.33)

Gene	Variant class	Controls	Cases	OR1 (95%CI)	p‐Value
ATM	Noncarriers	1,129	1,102	Ref.
	C0	43	47	1.1 (0.7, 1.6)	0.75
	C15‐C65	26	42	1.7 (1.0, 2.7)	0.05
CHEK2	Noncarriers	1,174	1,137	Ref.
	C0	7	23	3.4 (1.5, 8.0)	0.005
	C15‐C65	14	26	2.0 (1.1, 3.9)	0.03
PALB2	Noncarriers	1,181	1,168	Ref.
	C0	10	14	1.3 (0.6, 3.0)	0.51
	C15‐C65	5	15	3.3 (1.2, 9.0)	0.02

¹ Reference group: noncarriers of a variant in the tested gene; adjusting for ethnicity and age at inclusion.