Table 2.
Differences between randomization arms in T, N, and M categories by both laterality and sex, by laterality and overall
| Right | Left | |||||||
|---|---|---|---|---|---|---|---|---|
| Men | Women | Men | Women | |||||
| Screening (n = 95) | Control (n = 76) | Screening (n = 92) | Control (n = 86) | Screening (n = 345) | Control (n = 285) | Screening (n = 209) | Control (n = 167) | |
| T category | ||||||||
| T ≤ 2 | 22 (26) | 9 (13) | 20 (23) | 10 (14) | 140 (43·1) | 73 (27·2) | 71 (39·4) | 36 (23·5) |
| T > 2 | 63 (74) | 59 (87) | 66 (77) | 61 (86) | 185 (56·9) | 195 (72·8) | 109 (60·6) | 117 (76·5) |
| Missing | 10 | 8 | 6 | 15 | 20 | 17 | 29 | 14 |
| RR (control versus screening)* | ||||||||
| Sex and laterality stratum† | 1·17 (1·00, 1·38) | 1·11 (0·95, 1·30) | 1·28 (1·13, 1·44) | 1·33 (1·15, 1·56) | ||||
| Laterality stratum‡ | 1·14 (1·02, 1·28) | 1·30 (1·18, 1·43) | ||||||
| Overall§ | 1·23 (1·15, 1·33) | |||||||
| N category | ||||||||
| N0 | 48 (59) | 38 (58) | 43 (52) | 32 (46) | 194 (61·0) | 138 (52·1) | 94 (54·0) | 82 (55·4) |
| N ≥ 1 | 33 (41) | 28 (42) | 39 (48) | 37 (54) | 124 (39·0) | 127 (47·9) | 80 (46·0) | 66 (44·6) |
| Missing | 14 | 10 | 10 | 17 | 27 | 20 | 35 | 19 |
| RR (control versus screening)* | ||||||||
| Sex and laterality stratum† | 1·04 (0·70, 1·53) | 1·11 (0·80, 1·53) | 1·23 (1·02, 1·48) | 1·05 (0·82, 1·35) | ||||
| Laterality stratum‡ | 1·08 (0·84, 1·38) | 1·16 (1·00, 1·35) | ||||||
| Overall§ | 1·14 (1·00, 1·29) | |||||||
| M category | ||||||||
| M0 | 70 (76) | 57 (75) | 64 (70) | 60 (71) | 289 (84·5) | 215 (75·7) | 173 (82·8) | 123 (74·5) |
| M1 | 22 (24) | 19 (25) | 28 (30) | 25 (29) | 53 (15·5) | 69 (24·3) | 36 (17·2) | 42 (25·5) |
| Missing | 3 | 0 | 0 | 1 | 3 | 1 | 0 | 2 |
| RR (control versus screening)* | ||||||||
| Sex and laterality stratum† | 1·05 (0·61, 1·78) | 0·97 (0·61, 1·52) | 1·57 (1·14, 2·17) | 1·48 (1·00, 2·21) | ||||
| Laterality stratum‡ | 1·00 (0·70, 1·41) | 1·53 (1·19, 1·97) | ||||||
| Overall§ | 1·33 (1·08, 1·62) | |||||||
Values in parentheses are percentages unless indicated otherwise;
*
values in parentheses are 95 per cent confidence intervals.
†
Risk ratio (RR) estimated separately by sex and laterality for each stage category.
‡
RR adjusted for sex and estimated separately by laterality for each stage category.
§
RR adjusted for sex and laterality, and estimated separately for each stage category response.
A RR above 1 indicates a greater prevalence of the higher T, N or M category in control versus screening group.