Table 2.

Effect of day‐to‐day fasting SMBG variability (SDs) on rate of hypoglycaemia by low, medium and high tertiles

Hypoglycaemia	Day‐to‐day fasting SMBG variability tertile	Patients with T1D		Patients with T2D
		Estimate [95% CI]	P‐value	Estimate [95% CI]	P‐value
Overall symptomatic	Low	0.68 [0.58; 0.78]	P < 0.0001	0.28 [0.20; 0.40]	P < 0.0001
	Medium	Reference		Reference
	High	1.32 [1.19; 1.46]		2.23 [1.79; 2.78]
Nocturnal symptomatic	Low	0.45 [0.33; 0.62]	P < 0.0001	0.18 [0.09; 0.36]	P < 0.0001
	Medium	Reference		Reference
	High	1.59 [1.26; 2.01]		2.18 [1.56; 3.03]
Severe	Low	0.82 [0.49; 1.38]	P = 0.0053	0.33 [0.09; 1.22]	P = 0.1140
	Medium	Reference		Reference
	High	1.70 [1.11; 2.61]		1.31 [0.55; 3.09]

Abbreviations: CI, confidence interval; SMBG, self‐monitored blood glucose; T1D, type 1 diabetes; T2D, type 2 diabetes.

Data were based on the full analysis set. Number of episodes was analysed using a Poisson Model with logarithm of exposure time (100 years) as offset. The model included treatment, period, sequence, dosing time and SMBG as fixed effects, and participant as a random effect. SMBG was incorporated as a factor with three tertiles of the fasting SMBG variability, defined by the tertiles the square root of the mean value of the weekly variances of fasting SMBG values across the 16 weeks during the maintenance period.