Table 3.

Effect of day‐to‐day fasting SMBG variability (CV%) on rate of hypoglycaemia by low, medium and high tertiles

Hypoglycaemia	Day‐to‐day fasting SMBG variability (CV%) tertile	Patients with T1D		Patients with T2D
		Estimate [95% CI]	P value	Estimate [95% CI]	P value
Overall symptomatic	Low	0.69 [0.61; 0.78]	P < 0.0001	0.31 [0.22; 0.44]	P < 0.0001
	Medium	Reference		Reference
	High	1.18 [1.07; 1.30]		2.09 [1.67; 2.61]
Nocturnal symptomatic	Low	0.44 [0.33; 0.59]	P < 0.0001	0.26 [0.14; 0.47]	P < 0.0001
	Medium	Reference		Reference
	High	1.34 [1.08; 1.67]		2.05 [1.48; 2.84]
Severe	Low	0.59 [0.35; 0.98]	P = 0.0106	0.68 [0.22; 2.11]	P = 0.2705
	Medium	Reference		Reference
	High	1.28 [0.86; 1.90]		1.59 [0.65; 3.93]

Abbreviations: CI, confidence interval; CV, coefficient of variation; SMBG, self‐monitored blood glucose; T1D, type 1 diabetes; T2D, type 2 diabetes.

Data were based on the full analysis set. Number of episodes was analysed using a Poisson Model with logarithm of the exposure time (100 years) as offset. The model included treatment, period, sequence, dosing time and SMBG as fixed effects, and participant as a random effect. SMBG was incorporated as a factor with three tertiles of the fasting SMBG variability, defined by the tertiles the geometric mean value of the weekly CV% of fasting SMBG values across the 16 weeks during the maintenance period.