Table 2.
SNPs significantly associated with risk of colorectal adenomas in the study population
| SNP | Normal | Adenoma | |||||||
|---|---|---|---|---|---|---|---|---|---|
| (Gene) | Genetic model | Genotype | n | n | OR | 95% CI | p‐value1 | FDR2 | |
| rs10505477 | Recessive | A/A‐A/G | 653 | 436 | 1.00 | Reference | 0.014 | 0.033 | |
| CASC8 | G/G | 184 | 85 | 0.69 | 0.52 | 0.93 | |||
| rs6983267 | Recessive | G/G‐G/T | 647 | 427 | 1.00 | Reference | 0.010 | 0.033 | |
| CASC8 | T/T | 175 | 77 | 0.67 | 0.50 | 0.91 | |||
| rs13181 | Recessive | T/T‐G/T | 727 | 470 | 1.00 | Reference | 0.015 | 0.033 | |
| ERCC2 | G/G | 110 | 50 | 0.64 | 0.44 | 0.92 | |||
| rs1728785 | Recessive | C/C‐A/C | 773 | 503 | 1.00 | Reference | <0.001 | 0.015 | |
| ZFP90 | A/A | 62 | 18 | 0.41 | 0.24 | 0.72 | |||
| rs8180040 | Recessive | T/T‐A/T | 686 | 456 | 1.00 | Reference | 0.003 | 0.026 | |
| PTPN23 | A/A | 150 | 66 | 0.62 | 0.45 | 0.86 | |||
| rs16260 | Recessive | C/C‐A/C | 758 | 489 | 1.00 | Reference | 0.013 | 0.033 | |
| CDH1 | A/A | 79 | 34 | 0.59 | 0.38 | 0.91 | |||
| rs9929218 | Recessive | G/G‐A/G | 756 | 489 | 1.00 | Reference | 0.005 | 0.029 | |
| CDH1 | A/A | 83 | 34 | 0.55 | 0.36 | 0.84 | |||
OR: Odds ratio. CI: confidence interval. FDR: False Discovery Rate. n: number of individuals.
1
ORs and p‐values adjusted by age, gender, tobacco, alcohol, drugs use (NSAIDs and low‐dose ASA), and family history of CRC.
2
p‐values obtained after applying the False Discovery Rate (FDR) test for multiple corrections. FDR values <0.05 are highlighted in bold. Only those models with significant FDR p‐values are shown in the table.