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. 2018 Nov 26;144(3):489–502. doi: 10.1002/ijc.31858

Table 6.

SNPs associated with risk of adenoma subtypes in FDR of patients with family history of CRC (cases)

Adenoma Low risk adenoma High risk adenoma
SNP Genetic No* Yes** No* Yes**
(Gen) Model Genotype p‐value1 FDR2 n n OR 95% CI p‐value1 FDR2 n n OR 95% CI p‐value1 FDR2
rs10795668 Cod G/G 0.006 0.967 198 41 1.00 0.003 0.559 198 49 1.00 0.322 0.963
LINC00709 A/G 167 51 1.46 0.91 2.34 167 53 1.15 0.73 1.83
A/A 46 3 0.26 0.08 0.90 46 8 0.62 0.27 1.45
Dom G/G 0.544 0.369 198 41 1.00 0.490 0.013 198 49 1.00 0.868 0.997
A/G‐A/A 213 54 1.18 0.74 1.87 213 61 1.04 0.67 1.62
Rec G/G‐A/G 0.004 0.197 365 92 1.00 0.003 0.011 365 102 1.00 0.169 0.884
A/A 46 3 0.22 0.06 0.72 46 8 0.58 0.26 1.31
rs11255841 Cod T/T 0.028 0.967 211 43 1.00 <0.001 0.518 211 60 1.00 0.415 0.963
LINC00709 A/T 158 50 1.57 0.98 2.52 158 41 0.78 0.49 1.26
A/A 41 1 0.10 0.01 0.76 41 9 0.64 0.28 1.45
Dom T/T 0.754 0.506 211 43 1.00 0.388 0.002 211 60 1.00 0.216 0.997
A/T‐A/A 199 51 1.23 0.77 1.95 199 50 0.75 0.48 1.18
Rec T/T‐A/T 0.008 0.197 369 93 1.00 <0.001 0.002 369 101 1.00 0.391 0.979
A/A 41 1 0.08 0.01 0.61 41 9 0.71 0.33 1.57
Over T/T‐A/A 0.264 0.968 252 44 1.00 0.008 0.033 252 69 1.00 0.456 0.989
A/T 158 50 1.87 1.17 2.99 158 41 0.84 0.53 1.33
rs2228000 Cod G/G 0.189 0.981 224 40 1.00 0.030 0.054 224 59 1.00 0.455 0.963
XPC A/G 155 44 1.67 1.02 2.74 155 40 0.93 0.58 1.49
A/A 28 11 2.51 1.12 5.64 28 10 1.63 0.71 3.74
Dom G/G 0.180 0.982 224 40 1.00 0.013 0.047 224 59 1.00 0.937 0.997
A/G‐A/A 183 55 1.80 1.13 2.88 183 50 1.02 0.65 1.59
Adi GG,AG,AA 0.084 0.956 407 95 1.62 1.13 2.30 0.008 0.033 407 109 1.11 0.78 1.58 0.571 0.983
rs2427308 Dom C/C 0.363 0.982 251 68 1.00 0.038 0.033 251 62 1.00 0.845 0.997
CABLES2 C/T–T/T 156 26 0.59 0.35 0.98 156 47 1.05 0.67 1.65
Over C/C‐T/T 0.234 0.972 267 75 1.00 0.006 0.033 267 66 1.00 0.722 0.989
C/T 140 19 0.47 0.27 0.82 140 43 1.09 0.69 1.72

OR: odds ratio. CI: confidence interval. FDR: False Discovery Rate. n: number of individuals. Rec: recessive genetic model. Dom: dominant genetic model. Cod: codominant genetic model. Adi: additive genetic model. Over: overdominant genetic model. *Number of patients without adenomas ** Number of patients with colorrectal adenomas.

Only those SNPs with significant FDR p‐values are shown in the table.

1

ORs and p‐values adjusted by age, gender, tobacco, alcohol, drugs use (NSAIDs and low‐dose ASA). p‐values <0.05 are highlighted in bold.

2

p‐values obtained after applying the False Discovery Rate (FDR) test for multiple corrections. FDR values <0.05 are highlighted in bold.