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. 2019 Jun 14;10:1244. doi: 10.3389/fimmu.2019.01244

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Copyright © 2019 Avivar-Valderas, Martín-Martín, Ramírez, Del Río, Menta, Mancheño-Corvo, Ortiz-Virumbrales, Herrero-Méndez, Panés, García-Olmo, Castañer, Palacios, Lombardo, Dalemans and DelaRosa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD46 is a key mediator of complement cytotoxicity in ASC. (A) Graph showing percentage of 7-AAD positive parental and CD46^KO DonB ASC against increased concentration levels of W6/32 Ab. Prior analysis parental and CD46^KO DonB ASC were grown in the presence of 3 ng/mL IFNγ for 48 h (IFNγ) or left untreated (basal). (B) Sigmoidal curves displaying percentage of 7-AAD positive parental and CD46^KO ASC against EC₅₀ of W6/32 Ab (transformed from lineal to log₁₀). P-values were determined by the two-way ANOVA test. (C) Table showing half-maximal effective concentration of W6/32 Ab (ng/mL) of seven parental and the corresponding CD46^KO ASC in basal and IFNγ conditions. In columns 4 and 7, we calculated fold-change differences (CD46^KO EC₅₀/parental EC₅₀) and applied the color code showed in the right.