Figure 1.

HIF-1α-PPN transgene phenotypes. When induced to express the HIF-1α-PPN transgene by removal of doxycycline from the drinking water, some mice do not exhibit the expected phenotype, (A) as assessed by change in heart weight compared to body weight (n = 5 per group and time point), and (B) change in ventricular function (fractional shortening %; n = 5 per group and time point). Two-way ANOVA (A) and repeated measures two-way ANOVA (B) with Tukey’s post hoc test were used for statistical analysis. Data are expressed as mean ± SD; *#P < 0.05 (*between groups and ^#to baseline).