Fig. 2.

Discriminatory utility of a proposed CD4+ lymphocyte signature is primarily accounted for by three genes

(A) Dendrogram and heat map depicting results of hierarchical clustering of 279 early arthritis patients (columns) according to normalized expression of 12 signature genes in circulating CD4+ T cells (rows). Red dotted line identifies RA-enriched cluster highlighted in text. (B) Analogous result as for (A), based on normalized expression levels of three-gene signature only. (C) Scatterplots overlaid with non-parametric density plots separate RA patients and non-RA patients based on normalized expression alone, such that the two populations in each case preferentially occupy the top right and bottom left quadrants, respectively.