Figure 3. Correlation of neutralilzation potency and protection from SHIV challenge in macaque passive studies.

Data from multiple published passive antibody protection studies in macaques have been graphed showing the strong association between the potency of the antibody present in the sera at the time of challenge and the resulting protective efficacy. The fold over IC₅₀ was calculated as the passive antibody serum concentration at time of challenge (TOC) divided by the antibody neutralization potency (50% inhibitory concentration, [ID₅₀] in vitro), in pg/ml. Details of each study depicted here are detailed in Table 1.