Table 1.

Univariable and multivariable analysis of the prognostic impact of the KRAS‐4A splicing index in KRAS wild‐type patients with Stage I–III MSS CRCs

Variable	Five‐year overall survival
	Univariable analysis		Multivariable analysis1
	HR (95% CI)	p	HR (95% CI)	p
KRAS‐4A splicing index
High (above median)	1		1
Low (below median)	2.36 (1.07–5.18)	0.033	2.68 (1.18–6.09)	0.018
Gender
Female	1		1
Male	1.45 (0.69–3.03)	0.327	1.14 (0.54–2.41)	0.737
Age2	1.04 (1.00–1.07)	0.025	1.05 (1.01–1.09)	0.012
Location
Right	1		1
Left or rectum	1.27 (0.52–3.13)	0.597	1.85 (0.70–4.86)	0.213
Stage
Stage I and II	1		1
Stage III	1.20 (0.57–2.51)	0.633	1.26 (0.60–2.66)	0.536

¹Included all variables in table. N = 133.

²Continous variable.