Table 2.
Association between prepubertal BMI and pubertal development in children: Results from multivariate cox regression
| Variable | Menarche (n = 534) | Breast development (n = 418) | First spermatorrhea (n = 684) | Testicular development (n = 644) | ||||
|---|---|---|---|---|---|---|---|---|
| HRa (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Continuous variable | ||||||||
| BMI (kg/m2) | 1.205 (1.151‐1.261) | <.001 | 1.092 (1.045‐1.142) | <.001 | 1.054 (1.004‐1.106) | .033 | 1.098 (1.063‐1.135) | <.001 |
| Age (years) | 2.545 (2.259‐2.868) | <.001 | 1.726 (1.565‐1.903) | <.001 | 3.103 (2.586‐3.724) | <.001 | 2.681 (2.390‐3.007) | <.001 |
| Categorical variable | ||||||||
| Normal weightb | – | <.001 | – | .046 | – | .468 | – | .001 |
| Overweight | 2.605 (1.716‐3.956) | <.001 | 1.469 (1.024‐2.108) | .037 | 1.297 (0.818‐2.056) | .270 | 1.672 (1.204‐2.322) | .002 |
| Obese | 2.565 (1.603–4.103) | <.001 | 1.399 (0.913‐2.145 | .123 | 1.210 (0.714‐2.051) | .479 | 1.598 (1.135‐2.249) | .008 |
a
HR for BMI and different weight groups was adjusted for age.
b
Normal weight is the reference group.