Figure 1.

Schematic representation of the subcutaneous insulin PK model linked to the IGI model. CLG, insulin‐independent glucose clearance; CLGI, insulin‐dependent glucose clearance; CLI, endogenous insulin clearance; CLSCI, subcutaneous insulin clearance; kDJ, transfer rate constant from duodenum to jejunum; kGE, glucose effect compartment delay; kIE, insulin effect compartment delay; kJI, transfer rate constant from jejunum to ileum; kSD, gastric‐emptying rate constant; kaSCI, subcutaneous insulin absorption rate constant; KMG, amount of glucose giving 50% of maximum absorption rate; Q, intercompartmental glucose clearance; RAmax, maximum rate of absorption from each intestinal segment.