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. 2018 Nov 4;144(6):1345–1355. doi: 10.1002/ijc.31757

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© 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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The LIMK2 3´‐UTR SNP rs2073859 (A/G) influences miR‐135a binding and differentially influences LIMK2 expression. (a) The SNP rs2073859 is predicted to lie within the miR‐135a binding site. (b) The minimum free energy (MFE) change predicts stronger binding of miRNA‐135a to the G allele.(c) 3´‐UTR luciferase assay for miR‐135a binding to the G and A alleles of rs2073859.(d) Expression levels of the LIMK2 mRNA harboring rs2073859G or rs2073859A in heterozygous samples (TCCSUP, UM‐UC3 and EJ cells plus 10 tissue samples). (e) Correlation analysis of SNP variants and relative LIMK2 mRNA expression. (f) Half‐life of LIMK2 mRNA in BIU‐87 (GG genotype) and 5,637 (AA genotype) cells.