Table 2.
Participant Demographics and Disease Characteristics
| Characteristic | IRC Treatment (n = 60) | AM Arm (n = 60) | P Valuea |
|---|---|---|---|
| Male sex, No. (%) | 54 (90) | 58 (97) | .14 |
| Race/ethnicity, No. (%) | |||
| Non-Hispanic white | 36 (60) | 42 (70) | .05 |
| Non-Hispanic black | 7 (12) | 7 (12) | |
| Hispanicb | 16 (27) | 6 (10) | |
| Other | 1 (2) | 5 (8) | |
| Age, mean (range), y | 49.0 (25–78) | 50.5 (27–67) | .37 |
| ART, No. (%) | 54 (90) | 54 (90) | >.99 |
| Undetectable HIV viral load, No. (%) | 35 (59) | 42 (71) | .18 |
| Detectable viral load, median (range), copies/mL | 412 (77–1830) | 300 (82–1948) | .56 |
| CD4 cell count, median (IQR), cells/µL | |||
| Baseline | 669 (501–816) | 620 (514–736) | .34 |
| Nadir | 271 (106–395) | 300 (153–438) | .38 |
| History of AIDS diagnosis, No. (%) | 20 (33) | 19 (32) | .85 |
| History of HSIL, No. (%) | 29 (48) | 29 (48) | >.99 |
| Prior HSIL treatment, No. (%)c | 21/29 (72) | 24/29 (83) | .34 |
| Baseline No. of lesions, No. %d | |||
| 1 | 41 (68) | 32 (53) | .03 |
| 2 | 17 (28) | 19 (32) | |
| 3 | 2 (3) | 9 (15) |
Abbreviations: AM, active monitoring; ART, antiretroviral therapy; HIV, human immunodeficiency; HSIL, high-grade squamous intraepithelial lesion; IQR, interquartile range; IRC, infrared coagulation.
a P values determined with χ2 test or Wilcoxon rank sum test for categorical or continuous data, and with stratified (by site) Mantel-Haenszel test for number of lesions.
bAlthough the 4 categories of race/ethnicity did not significantly differ overall by arm, the difference between Hispanic and non-Hispanic participants was statistically significant (P = .02).
cOf those with a history of high-grade dysplasia.
dIdentified by local pathologist.