Table 2.
Unadjusted Odds Ratios and Associated 95% Confidence Intervals for the Association of Clinical and Treating Facility Characteristics with Allogeneic Hematopoietic Cell Transplantation in First Complete Remission Among Adolescents and Young Adults Diagnosed with Acute Lymphoblastic Leukemia, 2012–2013
| Characteristics | OR (95% CI) | p-value |
|---|---|---|
| Locationa | ||
| West | Reference | |
| East | 1.02 (0.62–1.68) | |
| Mid-southwest | 1.72 (0.99–2.97) | 0.146 |
| Age at diagnosis, years | ||
| 15–19 | Reference | |
| 20–24 | 1.44 (0.79–2.60) | |
| 25–29 | 3.03 (1.68–5.48) | |
| 30–34 | 3.21 (1.75–5.90) | |
| 35–39 | 4.03 (2.18–7.45) | <0.001 |
| Sex | ||
| Male | Reference | |
| Female | 1.18 (0.78–1.79) | 0.422 |
| Race/ethnicity | ||
| NH white | Reference | |
| Hispanic | 0.60 (0.40–0.91) | |
| NH black | 0.47 (0.17–1.30) | |
| Other | 1.38 (0.67–2.86) | 0.024 |
| Heath insurance | ||
| Private | Reference | |
| Public/no/unknown | 0.51 (0.34–0.76) | <0.001 |
| Incomeb | ||
| <55 | Reference | |
| 55–75 | 1.71 (0.85–3.42) | |
| ≥75 | 1.30 (0.62–2.71) | 0.201 |
| Comorbidities | ||
| No | Reference | |
| Yes | 1.59 (1.08–2.34) | 0.019 |
| ALL histology | ||
| B cell | Reference | |
| T cell | 0.73 (0.42–1.29) | 0.283 |
| ALL cytogenetic risk | ||
| Standard risk | ||
| High risk | 4.75 (3.13–7.21) | <0.001 |
| CNS involvement | ||
| No | Reference | |
| Yes | 0.81 (0.43–1.50) | 0.454 |
| Physician specialty | ||
| Pediatric oncology | Reference | |
| Adult hematology oncology | 2.61 (1.68–4.05) | <0.001 |
| Treating facility | ||
| Large teaching hospital | Reference | |
| Nonteaching hospital | 0.59 (0.31–1.11) | |
| Small teaching hospital | 0.81 (0.54–1.23) | 0.229 |
| Induction regimen | ||
| Asparaginase containing | Reference | |
| Hyper-CVAD | 2.86 (1.91–4.29) | |
| Other/unknown | 0.25 (0.07–0.92) | <0.001 |
Analyses exclude 32 patients who had relapse/progression or died within 3 months of diagnosis.
a
East: Atlanta (Metropolitan), Connecticut, New Jersey, Kentucky, Louisiana; Mid-southwest: Detroit (Metropolitan), Iowa, Utah, New Mexico; West: San Francisco (Oakland), San Jose-Monterey, Seattle (Puget Sound), Hawaii, Los Angeles, California other.
b
Census tract medium family income, in thousands of dollars.
OR, odds ratio; CI, confidence interval.