Table 3.
Multivariable-Adjusted Odds Ratios and Associated 95% Confidence Intervals for the Association of Patient, Clinical, and Treating Facility Characteristics with Allogeneic Hematopoietic Cell Transplantation in First Complete Remission Among Adolescents and Young Adults Diagnosed with Acute Lymphoblastic Leukemia, 2012–2013
| Characteristic | OR (95% CI) | p-Value |
|---|---|---|
| Age at diagnosis, years | ||
| 15–19 | Reference | |
| 20–24 | 1.21 (0.56–2.61) | |
| 25–29 | 1.92 (0.82–4.51) | |
| 30–34 | 1.69 (0.72–3.99) | |
| 35–39 | 2.76 (1.11–6.90) | 0.177 |
| Sex | ||
| Male | Reference | |
| Female | 0.72 (0.44–1.18) | 0.190 |
| Race/ethnicity | ||
| NH white | Reference | |
| Hispanic | 0.93 (0.55–1.55) | |
| NH black | 0.52 (0.17–1.61) | |
| Other | 1.98 (0.83–4.71) | 0.225 |
| Heath insurance | ||
| Private | Reference | |
| Public/no/unknown | 0.67 (0.41–1.09) | 0.105 |
| ALL cytogenetic risk | ||
| Standard risk | Reference | |
| High risk | 4.86 (3.02–7.83) | <0.001 |
| Physician specialty | ||
| Pediatric oncology | Reference | |
| Adult hematology oncology | 1.79 (0.87–3.66) | 0.113 |
| Treating facility | ||
| Large teaching hospital | Reference | |
| Nonteaching hospital | 0.42 (0.20–0.88) | |
| Small teaching hospital | 1.02 (0.63–1.65) | 0.052 |
| Induction regimen | ||
| Asparaginase containing | Reference | |
| Hyper-CVAD | 1.84 (1.07–3.16) | |
| Other/unknown | 0.23 (0.06–0.92) | 0.004 |
Adjusted for all variables in the table; analysis excludes 32 patients who had relapse/progression or died within 3 months of diagnosis.