Table 5.
Multivariable-Adjusted Hazard Ratios and 95% Confidence Intervals for the Association Between Patient, Clinical, and Treating Facility Characteristics with Overall Survival Among Adolescents and Young Adults Diagnosed with Acute Lymphoblastic Leukemia, 2012–2013
| Characteristic | HR (95% CI) | p-Value |
|---|---|---|
| Age at diagnosis, years | ||
| 15–19 | Reference | |
| 20–24 | 1.46 (0.63–3.38) | |
| 25–29 | 2.56 (1.15–5.73) | |
| 30–34 | 2.22 (0.95–5.20) | |
| 35–39 | 2.24 (0.91–5.50) | 0.162 |
| Sex | ||
| Male | Reference | |
| Female | 1.06 (0.65–1.73) | 0.801 |
| Race/ethnicity | ||
| NH white | Reference | |
| Hispanic | 1.23 (0.73–2.09) | |
| NH African American | 1.60 (0.61–4.20) | |
| Other | 0.59 (0.22–1.63) | 0.393 |
| Heath insurance | ||
| Private | Reference | |
| Public/no/unknown | 1.30 (0.80–2.10) | 0.293 |
| ALL cytogenetic risk | ||
| Standard risk | Reference | |
| High risk | 1.68 (1.00–2.82) | 0.051 |
| Physician specialty | ||
| Pediatric oncology | Reference | |
| Adult hematology oncology | 1.65 (0.81–3.34) | 0.165 |
| Treating facility | ||
| Large teaching hospital | Reference | |
| Nonteaching hospital | 2.15 (1.23–3.76) | |
| Small/medium teaching hospital | 0.81 (0.46–1.43) | 0.007 |
| Induction regimen | ||
| Asparaginase containing | Reference | |
| Hyper-CVAD | 1.41 (0.78–2.57) | |
| Other/unknown | 8.76 (4.66–16.48) | <0.001 |
| HCT in CR1 | ||
| No | Reference | |
| Yes | 1.88 (0.99–3.56) | 0.052 |
Adjusted for all variables in the table; HCT in CR1 was considered as time-dependent variable.