Table 1.
Pharmacokinetic of insulin in T1DM rats after SC administration of the free insulin, oral administration of IPUL-CS and IPUL-CST. Cmax: maximum plasma concentration; Tmax: time at which Cmax is attained; AUC: area under the plasma concentration-time curve.
| Formulation | Admin route |
Admin Vol (μL) |
Dose (IU/kg) |
Tmax (h) | Cmax (μIU/mL) |
AUC(0–10h)
(μIU·h/mL) |
oBA (%) |
|---|---|---|---|---|---|---|---|
| Free insulin | SC | 200 | 5 | - | 102 ± 6 | 274 ± 21 | 100 |
| IPUL-CS | Oral | 500 | 20 | 12 | 3 ± 2 | 43 ± 17 | 4 ± 2 |
| IPUL-CST | Oral | 500 | 20 | 9 | 45 ± 6 | 376 ± 43 | 34 ± 4 |
Each value represents the mean ± SEM