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. Author manuscript; available in PMC: 2019 Jun 21.
Published in final edited form as: Cogent Med. 2017 Apr 26;4(1):1317690.

Figure 4. Tissue organization and gene expression in the uterus of BPS-treated females is disrupted by an EE challenge.

Figure 4

A) Height of the uterine epithelium was significantly increased in BPS+EE females after an estrogen challenge compared to unchallenged females. In contrast, an estrogen challenge did not significantly affect height of the uterine epithelium in control+EE females. B) Quantification of Ki67 and TUNEL expression in the uterus of control and BPS-treated females after an EE challenge. C) Expression of three genes in uteri is shown relative to unchallenged females from the same perinatal exposure group. Estrogen treatment induced a non-significant decrease in ESR1 in the uterus of control+EE females, but not in BPS+EE females. In all panels, * indicates p<0.05, independent samples t-test comparing EE-challenged with non-challenged females from the same perinatal treatment group (control or BPS). δ indicates significant differences, p<0.05, between control+EE females and BPS+EE females. In all groups, n=5 per treatment.