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. Author manuscript; available in PMC: 2019 Jul 3.
Published in final edited form as: Adv Drug Deliv Rev. 2018 Jul 3;130:90–112. doi: 10.1016/j.addr.2018.06.023

Fig.1.

Fig.1

Examples of unintended interactions of drug delivery systems with major organs/tissues and their potential subsequent side effects. RES: reticuloendothelial system, BBB: the blood-brain barrier.