Table 2. Amino acid variations in the capsid coding region of carrier virus isolates compared to the outbreak virus collected in January 2014.
Number of virus isolates in which the changes occurred is in parentheses.
| Amino acid position in the capsid | Protein | Acute phase | Carrier phase | Significance | ||||
|---|---|---|---|---|---|---|---|---|
| Jan’ 2014 | Mar’ 2014 | May’ 2014 | Aug’ 2014 | Nov’2014 | Feb’2015 | |||
| Number of animals | 4 | 20 | 9 | 6 | 1 | 1 | ||
| 41 | VP4-41 | N | N(19)/D(1) | N | N | N | N | |
| 57 | VP4-57 | T | T | T(8)/A(1) | T | T | T | |
| 59 | VP4-59 | T | T | T | T | A(1) | T | |
| 61 | VP4-61 | N | N | N | N(4)/S(2) | N | N | Under selection pressure |
| 155 | VP2-70 | V | V(19)/A(1) | V | V | V | V | Site 2 |
| 159 | VP2-74 | P | P | P | P (5)/R(1) | P | P | |
| 162 | VP2-77 | G | G (19)/Q(1) | G(8)/Q(1) | G | G | G | Site 2, Under episodic selection |
| 163 | VP2-78 | C | C(12)/Y(7)/R(1) | C(7)/Y(2) | Y(6) | Y(1) | C | Under selection pressure |
| 167 | VP2-82 | E | E(18)/V(2) | E | E | E | E | |
| 175 | VP2-90 | V | V | V(8)/I(1) | V | V | V | |
| 181 | VP2-96 | D | D(19)/N(1) | D | D | D | D | |
| 219 | VP2-134 | K | K(18)/E(2) | K | K(4)/E(2) | K | K | Site 2, Under selection pressure |
| 222 | VP2-137 | L | L(18)/R(1)/Q(1) | L | L | L | L | Under episodic selection |
| 223 | VP2-138 | Y | Y(18)/S(2) | Y | Y | Y | Y | Under episodic selection |
| 224 | VP2-139 | Q | Q(19)/P(1) | Q | Q | Q | Q | |
| 257 | VP2-172 | K | K(19)/R(1) | K | K | K | K | |
| 267 | VP2-182 | M | M(18)/V(2) | M | M | M | M | |
| 276 | VP2-191 | T | T(18)/N(2) | T(8)/I(1) | T(7)/N(1) | T | T | Under episodic selection |
| 277 | VP2-192 | E | E(19)/G(1) | E | E | E | E | |
| 279 | VP2-194 | A | A | A(8)/P(1) | A | A | A | Under episodic selection |
| 299 | VP2-214 | F | F(19)/L(1) | F | F | F | F | |
| 338 | VP3-35 | N | N | N/D(1) | N | N | N | |
| 341 | VP3-38 | P | P(19)/A(1) | P | P | P | P | |
| 363 | VP3-60 | D | D(18)/G(2) | D | D | D | D | |
| 371 | VP3-68 | T | T(19)/A(1) | T(8)/A(1) | T | T | T | |
| 372 | VP3-69 | D | D | D | D(5)/G(1) | D | D | |
| 373 | VP3-70 | S | S | S(8)/P(1) | S | S | S | |
| 376 | VP3-73 | T | T(19)/M(1) | T(8)/M(1) | T(4)/M(1)/K(1) | T | T | Under selection pressure |
| 378 | VP3-75 | A | A(13)/T(7) | A(6)/T(3) | A | A | A | Under selection pressure |
| 379 | VP3-76 | Q | Q(19)/R(1) | Q(8)/H(1) | Q(5)/R(1) | Q | R(1) | Under selection pressure |
| 386 | VP3-83 | A | A(19)/S(1) | A | A | A | A | |
| 419 | VP3-116 | D | D(19)/N(1) | D | D | D | D | |
| 426 | VP3-123 | I | I | I | I(4)/V(2) | V(1) | I | Under episodic selection |
| 434 | VP3-131 | E | E(19)/D(1) | E(7)/D(1)/A(1) | E(3)/D(2)/A(1) | E | E | Under selection pressure |
| 437 | VP3-134 | K | K(18)/E(1)/N(1) | E(8)/N(1) | E | E | E | Under episodic selection |
| 468 | VP3-165 | A | A(19)/G(1) | A | A | A | A | |
| 469 | VP3-166 | D | D(19)/G(1) | D | D | D | D | Under episodic selection |
| 477 | VP3-174 | A | A(19)/V(1) | A(8)/T(1) | A(7)/V(1) | A | A | Under episodic selection |
| 481 | VP3-178 | T | T | T | T(5)/I(1) | T | T | |
| 490 | VP3-487 | F | F | F | F(5)/Y(1) | F | F | |
| 497 | VP3-194 | A | A(18)/G(2) | A | A | A | A | Under episodic selection |
| 498 | VP3-195 | D | D(18)/G(2) | D | D(5)/G(1) | D | D | Under episodic selection |
| 503 | VP3-200 | V | V | V(8)/I(1) | V | V | V | |
| 506 | VP3-203 | A | A | A | A | A | V(1) | |
| 510 | VP3-207 | K | K(19)/E(1) | K | K | K | K | |
| 528 | VP1-5 | G | G(18)/R(2) | G | G | G | G | Under episodic selection |
| 536 | VP1-13 | T | T | T(7)/S(1)/A(1) | T(5)/P(1) | T | T | Under episodic selection |
| 546 | VP1-23 | V | V | V | V(5)/A(1) | V | V | |
| 553 | VP1-30 | T | T(19)/P(1) | T | T | T | T | |
| 566 | VP1-43 | T | T | T(6)/I(3) | T | T | T | Site 3, Under selection pressure |
| 571 | VP1-48 | I | I | I(8)/T(1) | I(5)/T(1) | I | I | |
| 577 | VP1-54 | M | M | M | M | M | L(1) | |
| 582 | VP1-59 | H | H | H | H(5)/Y(1) | H | H | |
| 608 | VP1-85 | N | N(19)/S(1) | N | N(5)/S(1) | N | N | |
| 618 | VP1-95 | E | E | E(8)/V(1) | E | E | E | |
| 648 | VP1-125 | V | V(19)/A(1) | V | V | V | V | |
| 656 | VP1-133 | N | N | N(7)/D(1)/S(1) | N(5)/S(1) | N | N | Under episodic selection |
| 661 | VP1-138 | E | E(19)/G(1) | E(7)/G(1)/K(1) | E(2)/K(4) | E | E | Under selection pressure |
| 662 | VP1-139 | S | S | S(8)/N(1) | S(5)/N(1) | S | S | |
| 664 | VP1-141 | V | V | V(8)/A(1) | V | V | V | |
| 665 | VP1-142 | P | P(19)/S(1) | P | P | P | P | |
| 666 | VP1-143 | N | N(18)/K(2) | N(5)/K(3)/S(1) | N | K(1) | K(1) | |
| 671 | VP1-148 | L | L(18)/R(2) | L | L | L | L | Site 1, Under selection pressure |
| 672 | VP1-149 | Q | Q(19)/R(1) | Q | Q | Q | Q | Site 5 |
| 673 | VP1-150 | V | V(19)/A(1) | V | V | V | V | |
| 676 | VP1-153 | Q | Q(19)/R(1) | Q(8)/R(1) | Q(5)/R(1) | Q | Q | Under selection pressure |
| 678 | VP1-155 | A | A | A(8)/T(1) | A | A | A | |
| 679 | VP1-156 | A | A | A(8)/S(1) | A | A | A | |
| 681 | VP1-158 | R | R | R(8)/S(1) | R | R | R | |
| 695 | VP1-172 | R | R(19)/Q(1) | R(6)/Q(3) | R(5)/Q(1) | R | R | Under selection pressure |
| 699 | VP1-176 | L | L | L(8)/M(1) | L | L | L | |
| 720 | VP1-197 | S | S | S(8)/T(1) | S(5)/T(1) | S | S | Under selection pressure |
| 721 | VP1-198 | E | E(18)/G(2) | E | E | E | E | Under episodic selection |
| 728 | VP1-205 | I | I | I(8)/F(1) | I | I | I | |
| 732 | VP1-209 | P | P | P(8)/A(1) | P | P | P | |