Table 2. Toxicokinetic parameters of PTA and PTB after intravenous injection of PTA.
| Experiment 1 | Experiment 2 | |||||
|---|---|---|---|---|---|---|
| Heifer no | 4848 | 4849 | 4848 | 4849 | ||
| Dose | μmoles kg-1 | 0.527 | 0.527 | 0.231 | 0.141 | |
| PTA | λz | h-1 | 0.153 | 0.115 | 0.379 | 0.242 |
| AUC0-∞ | μmoles L-1 h | 1.39 | 1.35 | 0.829 | 0.42 | |
| MRT | h | 2.99 | 3.84 | 2.04 | 2.48 | |
| Cl (body) | L-1 h-1 kg-1 | 0.38 | 0.389 | 0.283 | 0.334 | |
| Vss | L kg-1 | 1.14 | 1.49 | 0.567 | 0.830 | |
| PTB | AUC0-∞ | μmoles L-1 h | 0.596 | 0.654 | 0.284 | 0.319 |
| AUC0-∞ PTB / AUC0-∞ PTA | 0.429 | 0.484 | 0.343 | 0.760 | ||
λz terminal slope; AUC0-∞ area under the curve from 0 to infinitive; MRT mean residence time; Cl (body) body clearance; Vss apparent volume of distribution at steady-state.