Table 3. Toxicokinetics parameters for PTB in plasma after oral administration of different doses of PTA.

		Experiment 3		Experiment 4		Experiment 5
		Bracken extract		Bracken extract		Dried bracken
Heifer no		4848	4849	4848	4849	4848	4849
PTA dose	μmoles kg-1	1.03		5.02		4.02
λz	h-1	0.234	0.100	0.382	0.290	0.308	0.28
AUC0-∞	μmoles L-1 h	0.177	0.367	0.594	0.657	0.897	0.428
MTT	h	3.82	4.55	2.89	3.02	3.29	3.58
Tmax	h	2.0	0.5	1.0	0.75	0.5	2.0
Cmax	μmoles L-1	0.028	0.043	0.160	0.174	0.182	0.074

λz terminal slope; AUC_0-∞ area under the curve from 0 to infinitive; MTT mean transit time; T_max time at maximum concentration; C_max maximum concentration; F bioavailability, was calculated by dividing the ratio of AUC_0-∞ oral by the dose and by ratio total PTA AUC_0-∞ IV by respective dose.