Table 1B:
Characteristics of alcoholic hepatitis patients for oxylipin analysis
| Treatment at admission | Histology | ||||
|---|---|---|---|---|---|
| Steroids, n (%), n=13 | 0 (0) | 2 | 1 (14.3) | ||
| Antibiotics, n (%), n=13 | 0 (0) | Lobular fibrosis | 0 | 0 (0) | |
| Infection at admission, n (%), n=12 | 1 (8.3) | 1 | 1 (14.3) | ||
| Clinical scores and outcome | 2 | 2 (28.6) | |||
| Model for end-stage liver disease (MELD), n=12 | 21.9 (11.7–29.6) | 3 | 4 (57.1) | ||
| MELD>21, n (%), n=12 | 7 (58.3) | Pericellular fibrosis | 0 | 2 (28.6) | |
| 30 day mortality rate, n (%), n=12 | 0 (0) | 1 | 5 (71.4) | ||
| 90 day mortality rate, n (%), n=12 | 2 (16.7) | Grade of steatosis | 1 | 3 (42.85) | |
| Histology | 2 | 3 (42.85) | |||
| Liver biopsy available, n (%) | 7 (53.8) | 3 | 1 (14.3) | ||
| Stage of fibrosis | 0 | 0 (0) | Mallory bodies | 0 | 1 (14.3) |
| 1 | 0 (0) | 1 | 6 (85.7) | ||
| 2 | 1 (14.3) | Bilirubinostasis | 0 | 1 (16.7) | |
| 3 | 1 (14.3) | 1 | 4 (66.6) | ||
| 4 | 5 (71.4) | 2 | 0 (0) | ||
| PMN infiltration | 0 | 1 (14.3) | 3 | 1 (16.7) | |
| 1 | 4 (57.1) | Ballooning | 0 | 7 (100) | |
| 2 | 2 (28.6) | 1 | 0 (0) | ||
| Inflammatory grade | 0 | 0 (0) | Giant mitochondria | 0 | 5 (100) |
| 1 | 6 (85.7) | 1 | 0 (0) | ||
Values are presented as median and range in brackets. The number of patients for which the respective data was available is indicated in the first column. Fibrosis stage, 0 no fibrosis, 1 portal fibrosis, 2 expansive periportal fibrosis, 3 bridging fibrosis, 4 cirrhosis. Lobular fibrosis, 0 no fibrosis, 1 zone 3 (centrilobular) fibrosis, 2 zone 2+3 (midzonal) fibrosis, 3 panlobular fibrosis. Pericellular fibrosis, 0 absent, 1 present. Steatosis, 1 mild < 33%, 2 moderate < 33–66%, 3 marked > 66%. Mallory bodies, 0 absent, 1 present. Bilirubinostasis, 0 no, 1 hepato-canalicular, 2 cholangiolar, 3 both. Ballooning, 0 occasional hepatocellular, 1 marked hepatocellular, 2 none present. Megamitochondria, 0 absent, 1 present. PMN infiltration, 0 no, 1 mild, 2 severe. Inflammation, 0 no, 1 mild, 2 severe. PMN, polymorphonuclear infiltration.