Figure 1. Structure and folding of the K_vAP channel.

(A) Top view of the tetrameric K_vAP channel. The structural model of the K_vAP channel previously described³¹ is shown. The structure illustrates the domain swap between the pore and voltage sensor domains of adjacent subunits in the K_vAP channel. (B) Topology map illustrating the domains and the structural features of a K_vAP channel subunit. Dashed lines are membrane boundaries. (C) The folding pathway of the K_vAP channel involves the stages of membrane insertion, secondary/tertiary folding and tetramerization. Structure figures were generated with VMD.⁶⁰