Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 7;8:e45946. doi: 10.7554/eLife.45946

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019, Grassmeyer et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

PMC Copyright notice

Figure 2. — (A) Example ERG recordings from control, Rod^Syt1CKO, and Cone^Syt1CKO retinas in response to 20 ms dim (left, 10⁻⁴ of maximum) and bright (right, 10⁻¹ of maximum) flashes. Downward gray arrows indicate a-waves and upward arrows indicate b-waves (a-waves are obscured by b-waves at low intensities). (B) Average b-wave flash intensity-response functions for the three genotypes. Maximum intensity b-waves: control: 777.7 ± 174.4 μV, Rod^Syt1CKO: 396.1 ± 44.3 μV, Cone^Syt1CKO: 354.0 ± 55.5 μV; Rod^Syt1CKO vs. control: p=0.10, Cone^Syt1CKO vs. control: p=0.06 (one-way ANOVA). (C) A-wave flash intensity-response curves for the three genotypes. Same legend as B). Maximum intensity a-waves: control: 266.7 ± 37.1 μV, Rod^Syt1CKO: 301.4 ± 25.4 μV, Cone^Syt1CKO: 261.6 ± 37.0 μV; Rod^Syt1CKO vs. control: p=0.72, Cone^Syt1CKO vs. control: p=0.99 (one-way ANOVA). (D) Isolated photoreceptor responses in control and Rod^Syt1CKO retinas. No means were significantly different (t-tests corrected for multiple comparisons). (E) B-wave/a-wave ratios for control (n = 10), Rod^Syt1CKO (n = 8), and Cone^Syt1CKO (n = 7) retinas. 10⁻² attenuation: control: 5.5 ± 0.68, Rod^Syt1CKO: 0.99 ± 0.24, Cone^Syt1CKO: 3.3 ± 0.61; Rod^Syt1CKO vs. control: p=0.0001, Cone^Syt1CKO vs. control: p=0.0005. 10⁻¹ attenuation: control: 3.0 ± 0.36, Rod^Syt1CKO: 1.3 ± 0.11, Cone^Syt1CKO: 1.6 ± 0.23; Rod^Syt1CKO vs. control: p=0.004, Cone^Syt1CKO vs. control: p=0.03. Maximum intensity: control: 2.4 ± 0.33, Rod^Syt1CKO: 1.3 ± 0.13, Cone^Syt1CKO: 1.5 ± 0.22; Rod^Syt1CKO vs. control: p=0.08, Cone^Syt1CKO vs. control: p=0.19 (repeated measures 2-way ANOVA). ***p≤0.0005, **p=0.004, *p=0.03.