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. 2019 Jun 7;8:e45946. doi: 10.7554/eLife.45946

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© 2019, Grassmeyer et al

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Figure 6. — Example I_A(Glu) recordings from control and Syt1-deficient rods in response to 5 (A) and 25 (B) ms depolarizing steps (−70 to −10 mV). (C) Example I_A(Glu) recordings from a Syt1-deficient rod evoked by 25 ms steps in control conditions and following bath application of the glutamate transport inhibitor, TBOA (300 μM). (D) I_A(Glu) charge transfer as a function of step duration in control rods, Rod^Syt1CKO rods, and in Rod^Syt1CKO rods in the presence of 300 μM TBOA. 5 ms: control: 555 ± 81 pC, n = 39 rods; Rod^Syt1CKO: 39.1 ± 29,3 pC, n = 31 rods; Rod^Syt1CKO + TBOA: 10.0 ± 2.9 pC, n = 6 rods; Rod^Syt1CKO vs. control: p<0.0001. 25 ms: control: 674 ± 105 pC, n = 37 rods; Rod^Syt1CKO: 203.7 ± 55.7 pC, n = 44 rods; Rod^Syt1CKO + TBOA: 9.6 ± 7.5 pC, n = 8 rods; Rod^Syt1CKO vs. control: p<0.0001 (t-tests corrected for multiple comparisons), Rod^Syt1CKO vs. Rod^Syt1CKO + TBOA: p=0.0012 (Welch’s t-test). **p<0.0001, *p=0.0012.