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. 2019 Jun 7;8:e45946. doi: 10.7554/eLife.45946

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© 2019, Grassmeyer et al

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Figure 8. — (A) Example current-voltage relationship of ramp-evoked I_Ca and step-evoked Q_Ca (a Boltzmann function adjusted for Ca²⁺ driving force was fit to Q_Ca) in a control cone. (B) Average Q_Ca as a function of step voltage for control and Cone^Syt1CKO cones. No means differed significantly (t-tests corrected for multiple comparisons). (C) Example ramp-evoked I_Ca traces from a control and Cone^Syt1CKO cone. (D) Ramp-evoked I_Ca peak amplitude (left) and V_0.5 values (middle), and step-evoked Q_Ca V_0.5 values (right) from control and Cone^Syt1CKO cones. I_Ca amplitude: Control: 33.1 ± 2.63 pA, n = 12; Cone^Syt1CKO: 42.5 ± 3.43 pA, n = 12; p=0.04 (t-test). I_Ca V_0.5: Control: −36.6 ± 0.83 mV, n = 12; Cone^Syt1CKO: −38.8 ± 0.84 mV, n = 11; p=0.07 (t-test). Q_Ca V_0.5: Control: −33.2 ± 0.98 mV, n = 12; Cone^Syt1CKO: −34.1 ± 2.01 mV, n = 7; p=0.67 (t-test). (E) Average I_Ca traces from control and Rod^Syt1CKO rods. (F) Ramp-evoked I_Ca peak amplitude from control and Rod^Syt1CKO rods. Control: 4.6 ± 0.87 pA, n = 7; Rod^Syt1CKO: 4.2 ± 0.88 pA, n = 11; p=0.76 (t-test).