Table 3.

Metabolic pathways associated with breast cancer risk

	Discovery		Validation
Metabolic pathway	P value	Impact factor	P value	Impact factor
Glycerophospholipid metabolism	2.17E-05	0.314	0.071	0.205
Sphingolipid metabolism	2.12E-04	0.283	Not observed
Citrate cycle (TCA cycle)	9.65E-04	0.236	0.012	0.090
Butanoate metabolism	0.013	0.108	0.076	0.040
D-Arginine and D-ornithine metabolism	0.014	0.500	Not observed
Alanine, aspartate and glutamate metabolism	0.017	0.003	0.119	0.003
Ascorbate and aldarate metabolism	0.019	0.049	0.310	0.033
Arginine and proline metabolism	0.031	0.096	0.011	0.120
Pyruvate metabolism	0.037	0.320	Not observed
Linoleic acid metabolism	0.046	0.656	0.005	0.656
Nicotinate and nicotinamide metabolism	0.081	0.017	0.095	0.038
Caffeine metabolism	0.084	0.045	0.413	0.015