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. Author manuscript; available in PMC: 2019 Sep 20.
Published in final edited form as: Annu Rev Biochem. 2019 Mar 18;88:725–783. doi: 10.1146/annurev-biochem-062917-011901

Figure 10.

Figure 10

Composite structure of the human NPC symmetric core. (a) A view of the entire NPC from the cytoplasmic side with docked crystal structures shown in ribbon representation. The gray surface represents the nuclear envelope. (b) A cutaway of the NPC viewed from the plane of the nuclear envelope with docked crystal structures shown in ribbon representation. Because Nup188 and Nup205 possess very similar overall shapes and cannot be distinguished at current resolutions, the assignment of the six positions per spoke is tentative. Figure adapted from Reference 41 with permission. Abbreviations: CNC, coat nucleoporin complex; CNT, channel nucleoporin heterotrimer; NPC, nuclear pore complex.