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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Neurobiol Dis. 2019 Mar 26;127:527–544. doi: 10.1016/j.nbd.2019.03.024

Figure 6. PERK and GADD34 deficiencies do not affect disease in G37R-42 mice.

Figure 6.

(A, B, D, E) Body weights of male (A, D) and female (B, E) mice. No significant differences were found in G37R-42/PERK+/‒ vs. G37R-42 mice (A, B) and in G37R-42/GADD34ΔC/ΔC vs. G37R-42 mice (D, E). n = 6–9 males and n = 6–11 females per genotype. Two-way RM-ANOVA with Tukey’s post hoc test. (C, F) There were no significant differences in the median survival times of G37R-42/GADD34ΔC/ΔC vs. G37R-42 mice (C) and in the median survival times of G37R- 42/GADD34ΔC/ΔC vs. G37R-42 mice (F). n = number of animals of the designated genotype. Log- rank (Mantel-Cox) test: P = 0.4481 (C), P = 0.2383 (F). N.S.=not significant. Data are shown as mean ± SEM. N.S. = not significant.