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Genetic determinants of PAS-resistance in Mtb spontaneous mutants and their susceptibility to PAS and INCAs (MIC in (μg/mL)
| Mutation |
||||
|---|---|---|---|---|
| WT Mtb |
folC (E153G) |
folC (I43T) |
thyX (−16 C->T) |
|
| PAS | 0.5 | 32 | 32 | 16 |
| UCP1172 | 0.03 | 0.125 | 0.015 | 1 |
| UCP1175 | 0.125 | 4 | 1 | 16 |
