Figure 3.

DLK deficiency causes changes in baseline transcription levels of injury-responsive genes.

Without injury, DEG analysis between WT and DLK KO identifies 107 significant DEGs (q < 0.01). Among them, 60 genes whose expression levels are significantly altered by nerve injury in WT mice (q < 0.01) are shown in the heatmap. The heatmap presents log₂(fold change) as indicated by the color key. In the left column, fold change was calculated by dividing the mean FPKM value in uninjured DLK KO mice by that in uninjured WT mice. In the right column, fold change was obtained by dividing the mean FPKM value in injured WT mice by that in uninjured WT mice. When a DEG appeared significant from multiple post-injury time points, a time point with the largest expression change was selected and the corresponding time point was indicated (#, expression is regulated in the opposite direction in unpresented time points). The fold change and FPKM data are provided in Supplementary Table 4.