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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: J Orthop Res. 2019 Apr 25;37(7):1465–1474. doi: 10.1002/jor.24305

Figure 5: Covalent modifications of DNA.

Figure 5:

Reversible methylation of DNA through maternal and patterning imprinting, as well as re-organization of methylation during embryogenesis and post-natal development, represents a canonical mechanism for epigenetic control. Active methylation (5-mC) is established by DNA methyl transferases (DNMTs) and so-called TET proteins that mediate DNA demethylation and generate several stable intermediates that generate a DNA methylome code (i.e., 5-mC, 5-hmC, 5-fC and 5-caC).